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May 2007: Volume 4, Number 2
   

TRITON TIDBITS FROM CAMPUS AND BEYOND

September 2007
Autism and Siblings

 
     

Most of us seek cues from other people when we’re faced with novel situations—and we do so automatically. For example, a young child who spies a caterpillar in the park might turn to look for a parent’s reaction before toddling over to examine it. And a grown-up, startled by a sudden jolt during a commercial flight, might glance at a flight attendant to determine from his expression whether or not it was something to be concerned about.

Called social referencing, the behavior typically emerges toward the end of the first year of life. But it is a behavior that, like several aspects of social cognition, is characteristically impaired in individuals with autism. Now, new research from the UCSD Infant Autism Project suggests that the brothers and sisters of autistic children, around 18 months, also do not reference adults as often as other babies do.

The finding is one of several from the project, headed by psychology professors Karen Dobkins and Leslie Carver. At 6 months, it appears that the siblings of autistic children process light-dark contrasts abnormally and are nearly twice as sensitive as typically developing children. And at 10 months, when babies usually respond much faster to faces, the siblings, by contrast, show much faster responses to objects.

Research has shown that first-degree relatives of people with autism often display milder, or sub-clinical, features of the disorder. Siblings, meanwhile, are at increased risk of receiving the diagnosis themselves: About 8 percent will go on to develop autism, as compared to about 0.5 percent of the general population.

The UCSD Infant Autism Project is currently focused on the siblings of autistic children and does not include data from those who are later diagnosed. But eventually, it is hoped that the data from the children with autism will help to uncover which traits or combination of traits result in the disorder and which might serve as the earliest markers for early diagnosis.

Carver and Dobkins take a neuro-developmental approach in their search for clues, investigating features of behavior and brain activity as they develop in the growing infant. Dobkins believes that a small modular problem early on could later results in a cascade of effects. “We’re trying,” she says, “to catch the culprits as the system is developing.”

— Inga Kiderra

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Neural & Behavioral Indicators of Autism
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"First-degree relatives of people with autism often display milder, or sub-clinical features of the disorder."

 

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